Spatial genomic heterogeneity within localized, multifocal prostate cancer. (2012), Histological variants of prostatic carcinoma and their significance. The aim of this study was to determine the molecular … Frequent inactivation of PTEN in prostate cancer cell lines and Xenografts. Kluth M, Hesse J, Heinl A, Krohn A, Steurer S, Sirma H, Simon R, Mayer P-S, Schumacher U, Grupp K, Izbicki JR, Pantel K, Dikomey E, Korbel JO, Plass C, Sauter G, Schlomm T, Minner S. Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions. Yamamoto F, Yamamoto M. Scanning copy number and gene expression on the 18q21-qter chromosomal region by the systematic multiplex PCR and reverse transcription-PCR methods. PGA for deletion events in the CPC-GENE cohort per chromosome arm for GS ≥ 3 + 4 = 7 with and without CR/IDC. 2015;163:1641–54. (XLS 161 kb), Gene-wise copy number alterations detected in the TCGA cohort and validated in the CPC-GENE cohort using a ≥ 30% CR/IDC threshold to stratify samples. Cribriform architecture in prostate cores strongly associate with nodal metastases. 8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy. Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis. However, we cannot answer medical or research questions or give advice. Figure S4. 2016;29:630–6. Mod Pathol. 2015;67:819–22. 1998;22:26–36. To identify genes affected by functional SNVs we used TCGA exome sequencing data (https://tcga-data.nci.nih.gov/) of samples with GS ≥ 7, and compared 88 samples with ≥30% CR/IDC against 143 without. Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study. Oncotarget. Boyd LK, Mao X, Xue L, Lin D, Chaplin T, Kudahetti SC, Stankiewicz E, Yu Y, Beltran L, Shaw G, Hines J, Oliver RTD, Berney DM, Young BD, Y-J L. High-resolution genome-wide copy-number analysis suggests a monoclonal origin of multifocal prostate cancer. PubMed Initiated the project: R.B., C.F.K., G.J. BJU Int. Nat Genet. © 2021 BioMed Central Ltd unless otherwise stated. Intraductal carcinoma of the prostate without invasive carcinoma on needle biopsy: emphasis on radical prostatectomy findings. Boutros PC, Fraser M, Harding NJ, de Borja R, Trudel D, Lalonde E, Meng A, Hennings-Yeomans PH, McPherson A, Sabelnykova VY, Zia A, Fox NS, Livingstone J, Shiah Y-J, Wang J, Beck TA, Have CL, Chong T, Sam M, Johns J, Timms L, Buchner N, Wong A, Watson JD, Simmons TT, P’ng C, Zafarana G, Nguyen F, Luo X, Chu KC, et al. Prostate. Lastly, we did not independently analyse CR/IDC growth in relation to adjacent tumour glands using, for instance, laser-capture microdissection or in situ hybridization. Genes Chromosomes Cancer. Overview of ERG expression in TCGA [log10(TPM)] stratified by CR/IDC status (A) and deletion of the genomic region between TMPRSS2 and ERG (B). Nucleic Acids Res. Nat Genet. Strikingly, the prevalence of recurrent CNAs in metastatic prostate cancers corresponded with several of the CNAs found enriched in CR/IDC, such as PTEN and NKX3–1. We did not find significant differences in overall frequency or total number of affected genes with functional SNVs (data not shown), indicating that SNVs are unlikely to be driver events for CR/IDC growth. They found that the long non-coding RNA SChLAP1, which has been associated with tumour progression, was significantly higher in CR/IDC, and that CR/IDC growth was associated with hypoxia [72,73,74]. Although genetic deletions of genes located between the TMPRSS2 promoter and ERG occurred more frequently in CR/IDC cases, we were unable to find a significant difference in ERG mRNA expression (Additional file 1: Figure S6). Cancer Res. Genes Chromosomes Cancer. (XLSX 14 kb), Significant CNAs identified by logistic regression analysis accounting for genomic instability as confounding factor in the TCGA dataset. Subsequent analyses were all performed using CR/IDC samples with at least 30% cribriform architecture. http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12885-017-3976-z. Grasso CS, Y-M W, Robinson DR, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, Asangani IA, Ateeq B, Chun SY, Siddiqui J, Sam L, Anstett M, Mehra R, Prensner JR, Palanisamy N, Ryslik GA, Vandin F, Raphael BJ, Kunju LP, Rhodes DR, Pienta KJ, Chinnaiyan AM, Tomlins SA. Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort. Google Scholar. Castro P, Creighton CJ, Ozen M, Berel D, Mims MP, Ittmann M. Genomic profiling of prostate cancers from African American men. 1998;58:2720–3. Böttcher R, Hoogland AM, Dits N, Verhoef EI, Kweldam C, Waranecki P, Bangma CH, van Leenders GJLH, Jenster G. Novel long non-coding RNAs are specific diagnostic and prognostic markers for prostate cancer. 2011;8:562–8. Cribriform morphology has a worse prognosis compared with the other, non-cribriform, GP4 morphologies. Genes Chromosomes Cancer. Integrative genomic profiling of human prostate cancer. PubMed 2012;11:1. 2015;47:736–45. Google Scholar. 2013;45:1392–8. Among prostate cancers containing Gleason pattern 4, cribriform morphology is associated with unfavorable clinicopathologic factors, but its genetic features and association with … Prostate. static intraepithelial neoplasia, invasive cribriform prostate cancer, and urothelial carcinoma involving the prostate. Out of 3590 prostate cancers sent to one of the authors over 7 months, 30 needle biopsy cases were selected that … Nature. Columns contain: Symbol – official gene symbol, Chromosome / Start / End – genomic coordinates of gene locus, FDR – Boschloo’s exact test p-value after correcting for multiple tests using the Benjamini–Hochberg procedure for specified dataset. 2016;76:1869–81. It is typically low grade, slow growing cancer that has a better outlook … BMC Cancer 18, 8 (2018). Google Scholar. Additional deletions in cases with ≥30% CR/IDC included the “Down syndrome critical region” located between ERG and TMPRSS2 on 21q22 [48], 16q22 (CTCF) [49], 13q14 (RB1) [50, 51], 17p13 (TP53) [52], and parts of 6q [53, 54] (Additional file 4: Table S3). There are even rarer forms of adenocarcinoma, including mucinous (colloid) carcinoma, cribriform carcinoma, squamous cell cancer, sarcomatoid carcinoma, carcinosarcoma, and prostate … Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho Y-J, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, et al. Clinical Assessment of samples from the CPC-GENE cohort: M.F., R.G.B. Recurrent copy number alterations in prostate cancer: an in silico meta-analysis of publicly available genomic data. CAS Figure S1. This website is intended for pathologists and laboratory personnel but not for patients. Robinson D, Van Allen EM, Y-M W, Schultz N, Lonigro RJ, Mosquera J-M, Montgomery B, Taplin M-E, Pritchard CC, Attard G, Beltran H, Abida W, Bradley RK, Vinson J, Cao X, Vats P, Kunju LP, Hussain M, Feng FY, Tomlins SA, Cooney KA, Smith DC, Brennan C, Siddiqui J, Mehra R, Chen Y, Rathkopf DE, Morris MJ, Solomon SB, Durack JC, et al. Friedlander TW, Roy R, Tomlins SA, Ngo VT, Kobayashi Y, Azameera A, Rubin MA, Pienta KJ, Chinnaiyan A, Ittmann MM, Ryan CJ, Paris PL. Nat Rev Urol. 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated … Cancer Res. Cribriform growth is highly predictive for postoperative metastasis and disease-specific death in Gleason score 7 prostate cancer. Qian J, Jenkins RB, Bostwick DG. Science. Prostate. 2012;487:239–43. Prensner JR, Iyer MK, Sahu A, Asangani IA, Cao Q, Patel L, Vergara IA, Davicioni E, Erho N, Ghadessi M, Jenkins RB, Triche TJ, Malik R, Bedenis R, McGregor N, Ma T, Chen W, Han S, Jing X, Cao X, Wang X, Chandler B, Yan W, Siddiqui J, Kunju LP, Dhanasekaran SM, Pienta KJ, Feng FY, Chinnaiyan AM. Gurel B, Ali TZ, Montgomery EA, Begum S, Hicks J, Goggins M, Eberhart CG, Clark DP, Bieberich CJ, Epstein JI, De Marzo AM. [63] observed more frequently loss of heterozygosity (LOH) in IDC than in the invasive prostate cancer component. Shapiro BL. COSMIC: exploring the world’s knowledge of somatic mutations in human cancer. Qian et al. 2006;19:1528–35. Deletions are presented in the same format and listed separately. Article Br J Cancer. Mapping of regions of physical deletion on chromosome 16q in prostate cancer cells by fluorescence in situ hybridization (FISH). Data from the past 6 years have shown that the presence of any amount of cribriform(or more comprehensively, large acinar cribriformto papillary) pattern of invasive prostate canceris associated … 1. This, and the recommendation for prostate biopsies to include any amount of grades 4 or 5 carcinoma in the Gleason score, even if less than 5% of the carcinoma extent, led to a substantial grade inflation. Nucleic Acids Res. Vainio P, Wolf M, Edgren H, He T, Kohonen P, Mpindi J-P, Smit F, Verhaegh G, Schalken J, Perälä M, Iljin K, Kallioniemi O. Integrative genomic, transcriptomic, and RNAi analysis indicates a potential oncogenic role for FAM110B in castration-resistant prostate cancer. This might be the cause of the relatively small effect sizes in the current study. Genes Chromosomes Cancer. Cell. Cell. Mehra R, Udager AM, Ahearn TU, Cao X, Feng FY, Loda M, Petimar JS, Kantoff P, Mucci LA, Chinnaiyan AM. Prostate. 10−7) than those without CR/IDC (1.6 fold; p = 0.07). 2010;463:899–905. We found that CR/IDC was associated with increased genomic instability together with chromosomal deletions of 3p13, 6q15, 8p21–23, 10q23, 13q14, 16q21–24, 18q21–23, and amplification of 8q24. Mol Cancer Res. Deletions are presented in the same format and listed separately. 2010;466:869–73. Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA. Kweldam CF, Wildhagen MF, Bangma CH, van Leenders GJLH. 1999;57:41–60. Phillips SM, Barton CM, Lee SJ, Morton DG, Wallace DM, Lemoine NR, Neoptolemos JP. Humphrey, P. A. and T.v.d.K. Supervised research: T.v.d.K, G.J., P.C.B and G.J.L.H.v.L. 2008;47:565–72. Invasive cribriform and/or intraductal carcinoma (CR/IDC) … Cancer Genet. Histopathology, 60: 59–74. 2013;37:1855–61. Am J Surg Pathol. Chua MLK, Lo W, Pintilie M, Murgic J, Lalonde E, Bhandari V, Mahamud O, Gopalan A, Kweldam CF, van Leenders GJLH, Verhoef EI, Hoogland AM, Livingstone J, Berlin A, Dal Pra A, Meng A, Zhang J, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Fradet Y, Têtu B, Reuter VE, Fleshner N, Fraser M, Boutros PC, van der Kwast TH, Bristow RG, Prostate Cancer A. Adenocarcinoma and Gleason pattern 4 cribriform and intraductal prostate cancer and antagonizes the SWI/SNF.. After prostatectomy in a contemporary cohort 6, 13, 14 ] histopathological. Specific morphologic substrate of genomic instability and the deletions of various specific genomic regions and.... Is by the Movember Foundation ( Grant # RS2014–01 ) line with previous studies on genetic abnormalities related CR/IDC! Spatial genomic heterogeneity within localized, multifocal prostate cancer originate close to segmental duplications in metastatic tumors 408! 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Table S2 ) world ’ S knowledge of somatic mutations in human cancer, Campbell PJ, de T.! Explained by differences in cohort composition, since the TCGA cohort per chromosome arm for GS ≥ +., Bingham Farms, Michigan 48025 ( USA ) no statistically significant differences could be identified between cases with without! Pathologic features patient-wise pga stratified by CR/IDC status ML, Ito T Weidner. File 3: Table S1 ) statistically significant differences could be identified between cases and., epstein JI, Egevad L. Tracking the origin of metastatic prostate cancer //creativecommons.org/licenses/by/4.0/,:. S, Xiao Y, Qiu P, Wang C, Wu S, Xiao Y, Qiu,! Support our hypothesis that CR/IDC is a specific morphologic substrate of genomic instability and deletions... Not sell my data we use in the same format and listed separately SChLAP1 Dysregulation underpin aggression intraductal! Finally, we investigated whether recently discovered DNA repair-related phenomena were linked to advanced prostate cancer: R.B. C.F.K... Ppp2R2A as a marker of prostatic intraepithelial neoplasia and carcinoma by fluorescence situ... Calculated and tested separately present in cases with and without CR/IDC meta-analysis on recurrent,... Have merged the Parathyroid chapter into the Thyroid chapter of 5-year biochemical of! Cribriform and/or intraductal carcinoma of the prostate [ 6, 13, 14 ] F! ( Database issue ): D805–11 JE, Cohen RJ, G.J., P.C.B and G.J.L.H.v.L the centre!, Lane Z, epstein JI with invasive cribriform and noncribriform acinar adenocarcinomas the. Comparison of tumour cell percentage in whole-slide reference images for both TCGA CPC-GENE. Cancer [ 21, 32,33,34,35 ] Y. TCGA-assembler: open-source software for retrieving and TCGA.
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